As a supporter, no - you need to make purchases in the UK for donations to be raised.
If you are registering a cause, you can register as long as the cause has a UK bank account, but your supporters must be UK-based to generate donations.
Other ways to phrase this question
Will this work in the USA
Will this work in Africa
I am from another country
I want to start but I'm seeing its not available in my country
Do you have a US equivalent
Can easy fundraising be used world wide
Can easyfundraising be used world wide
Does easyfundraising work for people in the USA
I live in the USA how can I donate